
What Makes This Casserole a Must-Try
Craving the rich, savory flavor of a loaded pizza—without having to roll out dough? This Meat Lovers Pizza Casserole turns all your favorite toppings into a baked, layered dish that’s satisfying, crowd-friendly, and ridiculously easy to make.
- Pizza Taste in a Casserole Form: All the classic pizza flavors baked into a cheesy pasta base.
- Protein-Packed and Filling: A meat trio of ground beef, sausage, and pepperoni gives it serious bite.
- Endlessly Adaptable: Toss in your favorite veggies or adjust the heat to your liking.
- One-Pan Simplicity: Minimal dishes and cleanup—always a win.
- Meal Prep Magic: Assemble ahead of time and bake when you’re ready.
Table of Contents
Ingredients Overview
Serves 6 to 8
You’ll Need:
- 1 lb ground beef
- ½ lb Italian sausage (remove casing if needed)
- 1 cup marinara sauce (jarred or homemade)
- 8 oz pasta (rigatoni or penne work best), cooked to al dente
- 1 cup pepperoni, chopped
- 1 cup shredded mozzarella
- ½ cup grated Parmesan
- 1 tsp Italian seasoning
- ½ tsp garlic powder
- Salt & black pepper, to taste
Optional Garnishes:
- Fresh basil
- Red chili flakes
- Extra pepperoni slices
How to Make It

Step 1: Preheat Oven
Start by setting your oven to 375°F (190°C). Lightly grease a large baking dish (around 9×13 inches).
Step 2: Cook the Meats
In a large skillet, cook ground beef and sausage together over medium heat until browned and cooked through. Drain off any grease.
Add the marinara sauce, garlic powder, Italian seasoning, and a bit of salt and pepper. Let the mixture simmer briefly to bring out the flavor—about 2–3 minutes.
Step 3: Layer the Ingredients
- Spread half of the cooked pasta in the bottom of your prepared baking dish.
- Spoon over half the meat sauce, sprinkle with half the pepperoni and mozzarella.
- Repeat the layers with remaining pasta, sauce, pepperoni, and mozzarella.
- Finish with Parmesan cheese sprinkled generously on top.
Step 4: Bake It
Place in the oven and bake uncovered for 20–25 minutes, until the cheese is bubbling and golden.
Step 5: Cool, Serve, and Enjoy
Let it sit for a few minutes before slicing into it. Add fresh basil, a touch of red pepper flakes, or extra pepperoni to finish it off.
Why It Works
- Big Flavor Layers: Using three types of meat brings complexity and richness.
- Perfect Pasta Texture: Al dente noodles hold their shape and absorb the sauce beautifully.
- Ultimate Cheese Pull: Mozzarella melts to perfection while Parmesan adds a salty finish.
Customization Ideas
Want to make it your own? Here are a few ways to switch things up:
- Add Veggies: Toss in sautéed mushrooms, spinach, or bell peppers.
- Make It Spicier: Try hot sausage or pepper jack cheese.
- Go Gluten-Free: Use a gluten-free pasta and double-check your sauce.
- Try Plant-Based: Use meatless crumbles and vegan cheese alternatives.
- Extra Creamy Version: Add a scoop of ricotta or a swirl of cream cheese to the meat sauce.
Expert Tips for Best Results
- Don’t Overcook the Pasta: It’ll finish softening in the oven.
- Go for Quality Sauce: A rich, flavorful marinara makes all the difference.
- Storage Tip: Keep leftovers in the fridge for up to 3 days. Reheat in the microwave or oven.
What to Serve With It
- Perfect Sidekicks: Garlic bread, Caesar salad, or roasted veggies.
- Brunch Twist: Serve with eggs and fruit for a savory breakfast casserole moment.
- Entertaining? Make it the centerpiece of your dinner table.
Final Thoughts
This Meat Lovers Pizza Casserole is the kind of meal that makes you feel like a kitchen hero without breaking a sweat. Big flavor, comforting texture, and total versatility—it’s comfort food done right.
Now It’s Your Turn
Have your own take on pizza-inspired dishes? Tried making this with a twist? Share your version, toppings, or tips below—we’re all here for the flavor inspiration! 🍽️